The Polish Journal of Aviation Medicine, Bioengineering and Psychology

Kwartalnik Polskiego Towarzystwa Medycyny Lotniczej

2013, Volume 19, Issue 4

Hypothalamic-Pituitary Sarcoidosis - Clinical and Aviation-Medical Decision Making Aspects

Łukasz Olendrzyński1, Katarzyna Piątek2
1Clinical Center, Military Institute of Aviation Medicine
2Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences

Autor korenspondencyjny: Łukasz Olendrzyński; Clinical Center, Military Institute of Aviation Medicine; email: lolendrz[at]wiml.waw.pl

DOI: 10.13174/pjamp.19.04.2013.4

Full text


Sarcoidosis is a multisystem disease of unknown etiology. It is characterized by the presence of noncaseating granulomas in the affected organs. Central nervous system involvement is observed in approximately 5% of patients. Granulomatous infiltration has a special predilection for the hypothalamus, pituitary gland, and, less commonly, pituitary stalk. Clinical symptoms include abnormal secretion of hormones of the anterior and posterior pituitary, including complete hypopituitarism. Neurosarcoidosis can mimic other, more common lesions. The mainstay of treatment is the use of steroids and supplements of the missing hormones. Despite the fact that hypothalamic-pituitary sarcoidosis is relatively rare, it should be taken into account in differential diagnosis during medical procedures in pilots and other aviation personnel. The variety of clinical symptoms that may occur in the course of neurosarcoidosis may lead to incorrect clinical diagnoses as well as significantly contribute to the reduction of flight safety.

Słowa kluczowe

sarcoidosis, sarcoidosis, hypothalamus, hypothalamus, pituitary, pituitary, hormones, hormones, glucocorticoids, glucocorticoids