2014, Volume 20, Issue 1

Antioxidant Properties of Cerebrolysin - an Old Drug with Newly Discovered Capabilities

Dominika BERENT¹, Krzysztof ZBORALSKI¹, Marian MACANDER¹
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¹Military Institute of Aviaton Medicine

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Streszczenie

Cerebrolysin (cere) is a porcine brain derived peptide-based drug approved outside US for dementia, acute stroke, and stroke rehabilitation and after brain injury resp. brain surgery. The clinical efficacy of cere is mainly attributed to the neurotrophic properties of the peptides in its content. However, there is still new evidence arising on antioxidant properties of cere. In this study we analyze a case of a 37-year old police officer with bilateral brain calcifications, who was treated intravenously with cere with a spectacular cognitive improvement and significant, but short, daily functioning improvement. The patient was diagnosed with Fahr disease (FD) in psychiatry ward and followed-up in outpatients for one year. It cannot be excluded, that clinical improvement was due to cere antioxidant influence on calcium, phosphorus, iron, zinc, aluminum, copper, and magnesium, described to be a content of brain calcifications in FD. We encourage to perform in vitro investigation on interaction between cerebrolysin and brain calcification to provide effective Fahr disease treatment scheme. To our best knowledge this is the first case report on FD treated with cere.

Słowa kluczowe

antioxidant effect, brain calcifications, cerebrolysin, neurodegeneration